Axon regeneration: Vaccinating against spinal cord injury
نویسنده
چکیده
Myelin is a potent inhibitor of axon regeneration, but has been viewed as just one of many factors that prevent regeneration after injury. So it comes as a surprise that immunization against myelin has been found to allow extensive axon regeneration after injury, without apparent autoimmune-induced demyelination.
منابع مشابه
Axon regeneration after spinal cord injury: insight from genetically modified mouse models.
The use of genetically modified mice to study axon regeneration after spinal cord injury has served as a useful in vivo model for both loss-of-function and gain-of-function analysis of candidate proteins. This review discusses the impact of genetically modified mice on axon regeneration after spinal cord injury in the context of axon growth inhibition by myelin, the glial scar, and chemorepelle...
متن کاملEffects of Local Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells in Combination with Low Level Laser Therapy in Repair of Experimental Acute Spinal Cord Injury in Rats
Objective- The aim of this study was to demonstrate the efficacy MSCs transplantation in combination with low level laser irradiation (low level laser irradiation) in repair of experimental acute spinal cord injury. Design- Experimental study. Animals- 28 adult male Wistar Rats. Procedures- A ballon- compression technique was used to produce an injury at the T8-T9 level of spi...
متن کاملExtrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury
Spinal cord injury is a devastating disease which disrupts the connections between the brain and spinal cord, often resulting in the loss of sensory and motor function below the lesion site. Most injured neurons fail to regenerate in the central nervous system after injury. Multiple intrinsic and extrinsic factors contribute to the general failure of axonal regeneration after injury. MicroRNAs ...
متن کاملGenetic mouse models for studying inhibitors of spinal axon regeneration.
The laboratory mouse has emerged as a primary model organism for studying axon regeneration after experimental spinal cord injury, owing to its genetic amenability. Mutant mouse models are contributing significantly to our understanding of the molecular mechanisms of axon regeneration failure in the adult mammalian central nervous system (CNS), in particular regarding the role of axon-growth in...
متن کاملEphA4 Blockers Promote Axonal Regeneration and Functional Recovery Following Spinal Cord Injury in Mice
Upregulation and activation of developmental axon guidance molecules, such as semaphorins and members of the Eph receptor tyrosine kinase family and their ligands, the ephrins, play a role in the inhibition of axonal regeneration following injury to the central nervous system. Previously we have demonstrated in a knockout model that axonal regeneration following spinal cord injury is promoted i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 10 شماره
صفحات -
تاریخ انتشار 2000